Not known Factual Statements About pkrrating
The interfacial residues are highly conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model where by activating RNA serves as being a scaffold to bind a number of PKR monomers, expanding